Hot 100 number-one hits of 1981 (USA)
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These are the Billboard magazine Hot 100 number one hits of 1981.
| Issue Date | Song | Artist |
| January 3 | (Just Like) Starting Over | John Lennon |
| January 10 | (Just Like) Starting Over | John Lennon |
| January 17 | (Just Like) Starting Over | John Lennon |
| January 24 | (Just Like) Starting Over | John Lennon |
| January 31 | The Tide Is High | Blondie |
| February 7 | Celebration | Kool & The Gang |
| February 14 | Celebration | Kool & The Gang |
| February 21 | 9 to 5 | Dolly Parton |
| February 28 | I Love a Rainy Night | Eddie Rabbitt |
| March 7 | I Love a Rainy Night | Eddie Rabbitt |
| March 14 | 9 to 5 | Dolly Parton |
| March 21 | Keep On Loving You | REO Speedwagon |
| March 28 | Rapture | Blondie |
| April 4 | Rapture | Blondie |
| April 11 | Kiss on My List | Daryl Hall and John Oates |
| April 18 | Kiss on My List | Daryl Hall and John Oates |
| April 25 | Kiss on My List | Daryl Hall and John Oates |
| May 2 | Morning Train (Nine to Five) | Sheena Easton |
| May 9 | Morning Train (Nine to Five) | Sheena Easton |
| May 16 | Bette Davis Eyes | Kim Carnes |
| May 23 | Bette Davis Eyes | Kim Carnes |
| May 30 | Bette Davis Eyes | Kim Carnes |
| June 6 | Bette Davis Eyes | Kim Carnes |
| June 13 | Bette Davis Eyes | Kim Carnes |
| June 20 | Medley: Intro Venus / Sugar Sugar / No Reply / I'll Be Back / Drive My Car / Do You Want To Know a Secret / We Can Work It Out /I Should Have Known Better / Nowhere Man / You're Going To Lose That Girl / Stars on 45 |
Stars on 45 |
| June 27 | Bette Davis Eyes | Kim Carnes |
| July 4 | Bette Davis Eyes | Kim Carnes |
| July 11 | Bette Davis Eyes | Kim Carnes |
| July 18 | Bette Davis Eyes | Kim Carnes |
| July 25 | The One That You Love | Air Supply |
| August 1 | Jessie's Girl | Rick Springfield |
| August 8 | Jessie's Girl | Rick Springfield |
| August 15 | Endless Love | Diana Ross and Lionel Richie |
| August 22 | Endless Love | Diana Ross and Lionel Richie |
| August 29 | Endless Love | Diana Ross and Lionel Richie |
| September 5 | Endless Love | Diana Ross and Lionel Richie |
| September 12 | Endless Love | Diana Ross and Lionel Richie |
| September 19 | Endless Love | Diana Ross and Lionel Richie |
| September 26 | Endless Love | Diana Ross and Lionel Richie |
| October 3 | Endless Love | Diana Ross and Lionel Richie |
| October 10 | Endless Love | Diana Ross and Lionel Richie |
| October 17 | Arthur's Theme (Best That You Can Do) | Christopher Cross |
| October 24 | Arthur's Theme (Best That You Can Do) | Christopher Cross |
| October 31 | Arthur's Theme (Best That You Can Do) | Christopher Cross |
| November 7 | Private Eyes | Daryl Hall and John Oates |
| November 14 | Private Eyes | Daryl Hall and John Oates |
| November 21 | Physical | Olivia Newton-John |
| November 28 | Physical | Olivia Newton-John |
| December 5 | Physical | Olivia Newton-John |
| December 12 | Physical | Olivia Newton-John |
| December 19 | Physical | Olivia Newton-John |
| December 26 | Physical | Olivia Newton-John |
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