Hormone-sensitive lipase

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Hormone-sensitive lipase is a protein found in the cytosol of adipocytes. It functions to hydrolyze triacylglycerols from the lipid droplet, freeing fatty acids and glycerols. It may be activated by two mechanisms.

In the first, it is phosphorylated by perilipin A, causing it to move to the surface of the lipid droplet, where it may begin hydrolyzing the lipid droplet.

Alternately, it may be activated by a cAMP-dependent protein kinase. This pathway is significantly less effective than the first, which is necessary to lipid mobilization in response to cyclic AMP.

[edit] References

  • Nelson, David L., and Michael M. Cox. Principles of Biochemistry. New York: W.H. Freeman.


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