High endothelial venules

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High endothelial venules, or HEVs, are a subtype of blood endothelium present within lymph nodes; used by various leukocytes to gain entry into the lymph node via the blood.[1]

The HEVs are made up of cuboidal endothelial cells, with various receptors to allow entry/rolling interactions between leukocytes and the endothelium.

High endothelial venules are found in lymph nodes and tonsils and Peyer's patches, but not in the thymus or spleen.[2]

[edit] References

  1. ^ UIUC Histology Subject 565
  2. ^ http://www.bu.edu/histology/m/schema03.htm#chart1
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Lymphatic system
Bone marrow | Thymus (Hassall's corpuscles) | Spleen (White pulp, Periarteriolar lymphoid sheaths, Marginal zone, Red pulp) | Tonsils (Palatine, Lingual, Adenoid)

Mucosa-associated lymphoid tissue: Gut-associated lymphoid tissue | Peyer's patches

Lymph nodes: Subcapsular sinus | Paracortex | head and neck (Cervical, Virchow's) | iliac (External, Common, Internal) | lumbar/paraaortic (Lateral aortic, Preaortic, Inferior mesenteric, Retroaortic) | inguinal (Deep, Superficial) | Axillary

Lymph vessels: Thoracic duct | Right lymphatic duct | Cisterna chyli  | Lumbar trunk | Intestinal trunk

Lymph | Lymphocytes | High endothelial venules | Immune system
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