Hartnup disease
From Wikipedia, the free encyclopedia
| ICD-10 | E72.0 |
|---|---|
| ICD-9 | 270.0 |
Hartnup disease, or Hartnup's disease, or Hartnup disorder, is a genetic metabolic disorder in the absorption of the amino acid tryptophan that can be, in turn, converted into Serotonin, Melatonin and Niacin. Niacin is a precursor to nicotinamide, a necessary component of NAD+.
[edit] Symptoms
Nicotinamide is necessary for neutral amino acid transporter production in the proximal renal tubules found in the kidney, and intestinal mucosal cells found in the small intestine. Therefore, a symptom stemming from this disorder results in increased amounts of amino acids in the urine.
Pellagra is also caused by low nicotinamide; this disorder results in dermatitis, diarrhea and dementia.
[edit] See also
[edit] External links
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