Haplogroup L0 (mtDNA)

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In human genetics, Haplogroup L0 is a human mitochondrial DNA (mtDNA) haplogroup.

Confusingly, some scientists use L0 to refer to an extinct haplogroup, while other scientists have identified haplogroups L0-L6 as existing in living humans^[1].

Contents 1 As extinct 2 As existing today 3 References 4 See also 5 External links

[edit] As extinct

Some scientists use L0 to refer to an extinct haplogroup. For example, one commercial testing company states, "Another haplogroup, L0, preceded L1, but is long since extinct."^[2] In this model, L1 is considered the haplogroup from which all living humans are descended.

[edit] As existing today

Some scientists use L0 to refer to the first offshoot of Mitochondrial Eve, estimated to have lived in Africa approximately 150,000 to 170,000 years ago.

Haplogroup L0 is most prevalent in East African populations (25% in Mozambique).^[3] Among Guineans, it has a frequency between 1% and 5%, with the Balanta group showing increased frequency of about 11% Haplogroup L0a has a Paleolithic time depth in East African populations of about 33,000 years and likely reached Guinea between 10,000 and 4,000 years ago.

[edit] References

1. ^ For example, Ethiopian Mitochondrial DNA Heritage: Tracking Gene Flow Across and Around the Gate of Tears states "Because (preHV)1 lineages occur in populations of the Near East, the Caucasus, and Mediterranean Europe—where African L0-L6 lineages are absent or rare—it is more likely that their presence in East Africa reflects a back-migration from the Near East rather than an in situ origin of (preHV)1 in Ethiopia (Richards et al. 2003)."
2. ^ GeneTree Haplogroup Table
3. ^ Rosa, A, Brehm A, Kivisild T, Metspalu E, Villems R (July 2004). MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region. Annals of Human Genetics 68 (4): 340-52. DOI:10.1046/j.1529-8817.2004.00100.x. PMID 1522515.

[edit] See also

• Human mitochondrial genetics
• Genealogical DNA test

Human mitochondrial DNA (mtDNA) haplogroups

mt-most recent common ancestor

L0

L1

L2

L3

M

N

M1

CZ

D

E

G

Q

A

I

W

X

R

N1

N2

Y

C

Z

B

JT

F

U

J

T

K

pre-HV

HV

H

V

[edit] External links

• L0 sequencing
• L0 tree
• MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region: "Based on the previous knowledge of African complete sequences paraphyletic clade L1 is split into two monophyletic units L0, capturing previously defined L1a and L1d lineages, and L1 clade that includes L1b and L1c clades..."
• Utility of JC polyomavirus in tracing the pattern of human migrations dating to prehistoric times: "The first axis of mtDNA, on the other hand, places the ancestral haplogroup L0 at the extreme left, since it gave rise to one sole lineage..."
• Mitochondrial DNA-like sequences in the nucleus (NUMTs): Insights into our African origins and the mechanism of foreign DNA integration (requires subscription): "haplogroup L0 mtDNAs, the haplogroup that we had previously concluded lies at the base of the human mtDNA. tree based on phylogenetic analysis..."