Halazepam


Halazepam
Systematic (IUPAC) name
9-chloro-6-phenyl-2-(2,2,2-trifluoroethyl)-2,5-diazabicyclo [5.4.0]undeca-5,8,10,12-tetraen-3-one
Identifiers
CAS number	23092-17-3
ATC code	N05 BA13
PubChem	31640
DrugBank	APRD01009
Chemical data
Formula	C₁₇H₁₂ClF₃N₂O
Mol. weight	352.7
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	Schedule IV (US)
Routes	Oral

Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam.^[1] While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them.^[2]

[edit] References

^ Greenblatt, D. J., A. Locniskar and R. I. Shader (June 12, 1982). "Halazepam, another precursor of desmethyldiazepam". Lancet 1 (8285): 1358-9. PubMed.
^ Fann, W. E., W. M. Pitts and J. C. Wheless (Mar-Apr 1982). "Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine". Pharmacotherapy 2 (2): 72-9. PubMed.

Benzodiazepines edit
Adinazolam, Alprazolam, Bentazepam, Bromazepam, Brotizolam, Camazepam, Chlordiazepoxide, Cinolazepam, Clobazam, Clonazepam, Clorazepate, Clotiazepam, Cloxazolam, Cyprazepam, Diazepam, Doxefazepam, Estazolam, Ethyl loflazepate, Etizolam, Fludiazepam, Flunitrazepam, Flurazepam, Flutazolam, Flutoprazepam, Gidazepam, Halazepam, Haloxazolam, Ketazolam, Loprazolam, Lorazepam, Lormetazepam, Medazepam, Mexazolam, Midazolam, Nimetazepam, Nitrazepam, Nordazepam, Oxazepam, Oxazolam, Phenazepam, Pinazepam, Prazepam, Quazepam, Temazepam, Tetrazepam, Tofisopam, Triazolam, Zolazepam