Talk:Haematopoiesis

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Contents 1 Image and college text 2 A schematic, perhaps? 3 Etymology 4 English vs. American spelling?

[edit] Image and college text

I deleted the following:

Embryologically, in roughly the 3rd-4th week of gestation the blood precursor cells arises from the yolk sac mesoderm. In esccense the first hematopoetic organ is the yolk sac, then the liver and spleen will take over in week 5 as a temporary but major hematopoietic tissues. Skipping over to about the 5th month of gestation, the bone marrow then becomes increasingly important as the hematopoietic organ. After birth, the blood cells are derived from stem cells of the bone marrow. The bone marrow also produces T-cells that migrate to the thymus where it becomes immunocompentent in the paracortex. Most cells mature in the bone marrow(become immunocompentent).

The main site for hematopoiesis is the bone marrow (after birth). Under normal conditions, the production of blood cells can adjust rapidly to the need of the body, increasing several-fold in a short time. The bone marrow is found in the meduallary canals of long bones and the cavities of cancellous bones. The first cavity to form is in the clavicle--this becomes clinically. Of clinical importance is the sternum when diagnosing certain types of Leukemia.

Taken from Dr. Yin's Notes at Ross University School of Medicine 11/08/2005.

The copyright status of these notes needs to be clarified, and wikification and sourcing is lacking. As for the haematopoiesis drawing - please don't upload drawings from your lecture notes on Wikipedia (unless your name is Picasso). Instead, consider OpenOffice or another graphic design package. JFW | T@lk 11:53, 11 May 2006 (UTC)

[edit] A schematic, perhaps?

This article needs a good schematic showing all (or as many as possible) cells that arise from haematopoiesis. I'm willing to draw this with guidance from others. But not by myself, as I'm not an expert and don't know how all these cells should look like when viewed through a microscope. Especially the progenitor cells. The schematic would contain the different cell groups (lymphoid, myeloid etc. and their progenitors) and the body compartment where these cells are found (the latter is not very hard). Optionally we can include the growth/differentiation factors that also play a part. I dunno if wikipedia already has this image, but I sure didn't find it. I've made a start at this and currently only have most (all?) of the final cells that arise from haematopoiesis. As this is yet a very rough and unorganised sketch, I haven't upped it to Wikipedia yet. You can see it here.

As I said, I'm not a haematologist and the different hematopoiesis schematics I've looked up so far differ in many ways and simply don't make sense to me. But we can collaborate and using some expert advice maybe we could come up with a correct and more "universal" schematic. You'll guide and I'll draw :D This could also be a candidate for an MCOTW. What you people say? Greets, A. Rad 09:43, 4 July 2006 (UTC)

What nice drawings! I recommend that you look at the diagram at the top of Pluripotential hemopoietic stem cell for further guidance. The diagram there is a product of the US government so you can freely adapt it. The diagram doesn't reflect all of the needed complexity, but in conjunction with the comment at the bottom of that diagram, it should be possible for you to come up with a decent draft. I'd also recommend you read Talk:Pluripotential hemopoietic stem cell, to see some of the mild disagreements people have over classification. --Arcadian 10:18, 4 July 2006 (UTC)

Thanks, I made those in XaraX¹ ;) Thanks for the info. I read those pages and they pretty much sum up what I mean when I said that there are different schematics on hematopoiesis. E.g. looking at that image, the myeloblast can form a progranulocyte which can form a granulocyte(neutro/eo/baso), whereas some schematics suggest myeloblast > N.Promyelocyte > N.Myelocyte > N.Metamyelocyte > N.Band > Neutro, and myeloblast > eo and baso seperately. The image on PPHSC notes the Polychromatic erythroblast as the progenitor of the RBC, while other schematics say it's the polychromatic erythrocyte. Which to include? I know blast comes before cyte. Maybe include both? And there's of course the "CFU-" notation. I'm not sure how correct the schematic will become without any error checking by other wikipedians. Greets, A. Rad 08:53, 5 July 2006 (UTC)

Hi, I've found some sites that have pictures of all the progenitors (I think), so I can start drawing as soon as I've studied each progenitor carefully. I think it can be useful to keep anyone who's interested in this diagram up to date with the progress. I've uploaded an image containing a sketch of the current hematopoietic pathways (not complete) that I'm working on, along with my progress on drawing different cells. Anyone who's interested can view this image and comment on the drawing on the cells that I have drawn incorrectly. It is not complete and therefore not suitable for uploading on Wikipedia yet. Once in a while, I'll update the image by overwriting it and edit this (my own) comment by adding a new signature (~~~~) which shows the date and time of the update. Let's hope this works ;)

The image with the current progress of the schematic can be found here. Looking forward to any comments. Greets, A. Rad 12:30, 30 July 2006 (UTC)

The diagram is done, uploaded and inserted in this article. It still needs expert verification and/or peer review. --A. Rad 13:44, 13 August 2006 (UTC)

[edit] Etymology

This page has no etymology for Haematopoiesis. Haema- clearly means blood; poiesis probably means generation, but my knowledge of Latin and Greek does not allow me to name its etonym — my guess is it's Latin. Rintrah 12:00, 26 September 2006 (UTC)

[edit] English vs. American spelling?

Without wanting to get into an edit war, why does "Hematopoiesis" redirect to the English "Haematopoiesis" spelling instead of the other way around? Isn't Wikipedia based in the U.S. and aren't most of the readers American?

From Wikipedia:How to copy-edit: Note that the English language edition of Wikipedia has no preference for American, British, or other variants of the language. It is important, however, for usage to remain consistent within a single page.. I, myself, prefer British spelling, although I am an Australian. Rintrah 03:33, 8 October 2006 (UTC)