GTP cyclohydrolase I

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GTP cyclohydrolase I (GTP 7,8-8,9-dihydrolase, EC 3.5.4.16) is an enzyme that is part of the folate and biopterin biosynthesis pathways. It is responsible for the hydrolysis of guanosine triphosphate (GTP) to form 7,8-dihydroneopterin 3'-triphosphate.

The reaction performed by GTP cyclohydrolase I. The important carbons relative to the transformation are numbered for reference.

[edit] References

• Voet, D.; Voet, J.G. (2004). Biochemistry (3rd ed.). John Wiley & Sons. ISBN 0-471-39223-5
• EC 3.5.4.16 IUBMB Enzyme Nomenclature

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