Griseofulvin

From Wikipedia, the free encyclopedia

You have new messages (last change).
Griseofulvin chemical structure
Griseofulvin
Systematic (IUPAC) name
(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,
4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
Identifiers
CAS number 126-07-8
ATC code D01AA08 D01BA01
PubChem 441140
DrugBank APRD01004
Chemical data
Formula C17H17ClO6 
Mol. weight 352.766 g/mol
Pharmacokinetic data
Bioavailability Highly variable (25 to 70%)
Metabolism Hepatic demethylation and glucuronidation
Half life 9-21 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B3 (Au), C (U.S.)
Legal status

POM (UK), ℞-only (U.S.)
Routes Oral

Griseofulvin is an antifungal drug. It is used both in animals and in humans, to treat ringworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.

It is administered orally.

It binds to keratin in keratin precursor cells and makes them resistant to fungal infections. It is only when hair or skin is replaced by the keratin-griseofulvin complex that the drug reaches its site of action. Griseofulvin will then enter the dermatophyte through energy dependant transport processes and bind to fungal microtubules. This alters the processing for mitosis and also underlying information for deposition of fungal cell walls.

Known side effects:

  • Hives
  • Skin rashes
  • Confusion
  • Dizziness
  • Diarrhea
  • Fatigue
  • Headache
  • Impairment of performance of routine activities
  • Inability to fall or stay asleep
  • Nausea
  • Oral thrush (yeast infection of the mouth)
  • Upper abdominal pain
  • Vomiting
  • Swelling
  • Itching
  • Tingling in the hands or feet
  • Loss of taste sensation
Pills  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.


Antifungals (D01 and J02) edit
Antibiotics: Griseofulvin, Hitachimycin, Natamycin, Nystatin
Topical Azoles: Clotrimazole, Econazole, Fluconazole, Ketoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole
Other topicals: Ciclopirox, Ethylparaben, Flucytosine, Salicylic acid, Selenium sulfide, Terbinafine, Tolnaftate
For systemic use: Amphotericin B, Anidulafungin, Caspofungin, Griseofulvin, Itraconazole, Terbinafine, Voriconazole
Other: Posaconazole, Thiabendazole, Tea tree oil
Retrieved from "http://en.wikipedia.org../../../g/r/i/Griseofulvin.html"
In other languages