Gramicidin S

From Wikipedia, the free encyclopedia

Gramicidin S is a derivative of gramicidin, produced by the spore Bacillus brevis var. G.-B. Gramicidin S is a cyclodecapeptide, which is different from Gramicidin D which is a linear peptide which forms a beta helix in cellular membranes. The exact mechanism by which Gramicidin S works is not well known.

It has a molecular mass of ca. 1,300 and is a transparent yellow or light yellow liquid and is usually encapsulated in two-percent sterile spirit solution. First used in 1943 by USSR during World War II (thus is also known as Gramicidin S). It also exists in the form of pills (Latin: tabulettae Gramicidini) and paste (pasta Gramicidini). The last could be also used as a contraceptive, being introduced into vagina by the special syringe.