Glucosidases
From Wikipedia, the free encyclopedia
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Acid alpha-glucosidase
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| Identifiers | |
| Symbol(s) | GAA |
| Entrez | 2548 |
| OMIM | 606800 |
| RefSeq | NM_000152 |
| UniProt | P10253 |
| Other data | |
| EC number | 3.2.1.20 |
| Locus | Chr. 17 q25.2-q25.3 |
Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1. They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.
α-glucosidases are targeted by alpha-glucosidase inhibitors to control diabetes mellitus type 2.
Members include:
- α-Amylase (EC 3.2.1.1 ) is a digestive enzyme in mammals.
- β-Amylase (EC 3.2.1.2 ) is a plant enzyme to break down starch.
- γ-Amylase (EC 3.2.1.3 ) is a digestive enzyme.
- Cellulase (EC 3.2.1.4 ) breaks down cellulose from plant material.
- Acid α-glucosidase (EC 3.2.1.20 ) is associated with Glycogen storage disease type II.
- Lactase (EC 3.2.1.23 ) one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance.
- Pullulanase (EC 3.2.1.41 ) has been used as a detergent.
