Glucocerebrosidase

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Acid β-glucosidase, drawn from PDB 1OGS.
Acid β-glucosidase, drawn from PDB 1OGS.

Glucocerebrosidase (also called glucosylceramidase or D-glucosyl-N-acylsphingosine glucohydrolase) is an enzyme (EC 3.2.1.45) that is needed to break down the chemical glucocerebroside by hydrolysis. It is localized in the lysosome and has a molecular weight of 59700 Da. It is the enzyme that is defective in cells of patients with Gaucher disease.

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