Glucan

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A glucan molecule is a polysaccharide of D-glucose monomers linked by glycosidic bonds. The following are glucans:

[edit] Medical applications

Glucans form part of the cell wall of certain medically important fungi, including Candida and Aspergillus species. An assay to detect the presence of (1→3)β-D-glucan in the blood has been produced as a means of diagnosing invasive fungal infection in patients.[1][2][3]

[edit] References

  1. ^ Obayashi T, Yoshida M, Mori T, et al. (1995). "Plasma (13)-beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes". Lancet 345: 17–20.
  2. ^ Ostrosky-Zeichner L, Alexander BD, Kett DH, et al. (2005). "Multicenter clinical evaluation of the (1→3)β-D-glucan assay as an aid to diagnosis of fungal infections in humans". Clin Infect Dis 41: 654–659.
  3. ^ Odabasi Z, Mattiuzzi G, Estey E, et al. (2004). "Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome". Clin Infect Dis 39: 199–205.


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