Fundic glands

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Fundic glands

H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation
Latin	glandulae gastricae
Gray's	subject #247 1166
Dorlands/Elsevier	g_06/12391406

The fundus glands (or fundic glands, or gastric glands) are found in the body and fundus of the stomach.

They are simple tubes, two or more of which open into a single duct.

1 Structure
2 Pathology
3 Types of cells
4 Additional images
5 External links

[edit] Structure

The duct, however, in these glands is shorter than in the pyloric variety, sometimes not amounting to more than one-sixth of the whole length of the gland; it is lined throughout by columnar epithelium.

The gland tubes are straight and parallel to each other.

[edit] Pathology

Fundic gland polyposis is a medical syndrome where the fundus of the stomach develops many polyps.

[edit] Types of cells

Location	Name	Description	Secretion	Staining
Isthmus	mucous cells	In gastric pits.	mucus gel layer	Clear
Neck	parietal (oxyntic) cells	Between the chief cells and the basement membrane, larger oval cells, which stain deeply with eosin, are found; these cells are studded throughout the tube at intervals, giving it a beaded or varicose appearance. These are known as the parietal cells or oxyntic cells, and they are connected with the lumen by fine channels which run into their substance.	gastric acid and intrinsic factor	Acidophilic
Base	chief (zymogenic) cells	At the point where they open into the duct, which is termed the neck, the epithelium alters, and consists of short columnar or polyhedral, granular cells, which almost fill the tube, so that the lumen becomes suddenly constricted and is continued down as a very fine channel. They are known as the chief cells or central cells of the glands.	pepsinogen, rennin	Basophilic
Base	enteroendocrine (APUD) cells	-	hormones	-

[edit] Additional images

A fundus gland. A. Transverse section of gland.

Layers of stomach wall

[edit] External links

Dictionary at eMedicine gastric+glands
Histology at OU 50_02 - "Fundic stomach"
Organology at UC Davis Digestive/mammal/stomach4/stomach2 - "Mammal, ruminant stomach (LM, High)"
Histology at BU 11301ooa - "Digestive System: Alimentary Canal - fundic stomach"
Veterinary Histology at vt.edu
Details at luc.edu - see slide #42

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