FTY720

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FTY720 (fingolimod) is a novel immunosuppressant drug that causes lymphopenia by redirecting lymphocytes from circulation to the lymph nodes. It is a chemical modification of the ISP-1 metabolite of the fungus Isaria sinclairii.(Dong Chong Xia Cao) It is a structural analogue of sphingosine and gets phosphorylated by sphingosine kinase 2 1 21 in the cell. The molecular biology of this biological function lies in FTY720's activity at one of the five sphigosine-1-phospate receptors--S1P1. [1] It is currently in phase III clinical trials as monotherapy for relapsing remitting multiple sclerosis. In a previous phase III trial of kidney transplantation, FTY720 was found to be not better than existing standard of care.

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