Framed! Great Escape

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The Framed! Great Escape was a 2001 webcomic crossover, most likely the largest such event ever. In total, over sixty webcomics were involved, with Damonk's metafictional Framed! and its characters at the core. As may be inferred from the title, the event began with the escape of the Framed! characters Frank, Mike, Derek, and Allison from their webcomic. They proceeded to wreak havoc throughout several other webcomics, which triggered further subplots.

[edit] Sources

Comixpedia article on Damonk

The event's beginning