Fomivirsen

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Image:Fomivirsen.png
Fomivirsen
Systematic (IUPAC) name
?
Identifiers
CAS number	160369-77-7
ATC code	S01 AD08
PubChem	?
Chemical data
Formula	?
Mol. weight	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	B2
Legal status
Routes	?

Fomivirsen (brand name "Vitravene") is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS.

It is an oligonucleotide that blocks transcription of viral mRNA by bindng to a coding segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.

[edit] See also

retinitis

[edit] External links

Diagram
MedlinePlus DrugInfo uspdi-203675
DDB 31313
(2001) "Fomivirsen.". Drugs Today (Barc) 37 (4): 245-255. PMID 12768225.
Geary R, Henry S, Grillone L (2002). "Fomivirsen: clinical pharmacology and potential drug interactions.". Clin Pharmacokinet 41 (4): 255-60. PMID 11978144.
(2002) "Randomized dose-comparison studies of intravitreous fomivirsen for treatment of cytomegalovirus retinitis that has reactivated or is persistently active despite other therapies in patients with AIDS.". Am J Ophthalmol 133 (4): 475-83. PMID 11931781.
Roehr B (1998). "Fomivirsen approved for CMV retinitis.". J Int Assoc Physicians AIDS Care 4 (10): 14-6. PMID 11365956.

Antivirals (primarily J05A, also S01AD and D06BB) edit

Anti-herpesvirus agents		Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine
Anti-influenza agents		Amantadine, Oseltamivir, Peramivir, Rimantadine, Zanamivir

Antiretroviral drugs	NRTIs	Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine
	NtRTIs	Tenofovir
	NNRTIs	Efavirenz, Delavirdine, Nevirapine
	PIs	Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
	Fusion inhibitors	Enfuvirtide

Other antiviral agents		Adefovir, Fomivirsen, Imiquimod, Inosine,Interferon, Podophyllotoxin, Ribavirin, Viramidine