Follistatin
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| Follistatin | |
|---|---|
 The Structure Of The Follistatin:Activin Complex |
|
| Other names: | FS, Activin-binding protein |
| Genetic data | |
| Gene code: | HUGO code:FST |
| Protein Structure/Function | |
| Structure: | Follistatin:Activin Complex structure |
| Protein type: | Growth factor |
| Functions: | Regulates members of the TGF beta superfamily ligands |
| Domains: | 3 FOLN domains, 3 KAZAL domains |
| Other | |
| Taxa expressing: | Homo Sapiens; homologs: many metazoan phyla |
| Cell types: | many, placenta, blood, ovary, liver, testis |
| Subcellular localization: | extracellular |
| Molecular interactions: | Activin, inhibin, BMP5 |
| Medical/Biotechnological data | |
| Diseases: | polycystic ovary syndrome (PCOS) |
Follistatin is a single chain gonadal protein that inhibits Follicle-stimulating hormone release. It binds to and antagonizes Activin, which enhances FSH secretion. There are three known isoforms created by alternative splicing.
| Identifiers | |
| Symbol(s) | FST |
| Entrez | 10468 |
| OMIM | 136470 |
| RefSeq | NM_013409 |
| UniProt | P19883 |
| Other data | |
| Locus | Chr. 5 q11.2 |
| TGF beta signaling pathwayedit | |
|---|---|
| TGF beta superfamily of ligands: | |
| Activin A | Activin B | Anti-müllerian hormone | BMP2 | BMP3 | BMP4 | BMP5 | BMP6 | BMP7 | BMP8a | BMP8b | BMP10| BMP15 | GDF1 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDF10 | GDF11 | GDF15| Inhibin A | Inhibin B | Myostatin | Nodal | TGFβ1 | TGFβ2 | TGFβ3 | |
| Type II receptors: ACVR2A | ACVR2B | AMHR2 | BMPR2 | TGFBR2 | TGFBR3 | |
| Type I receptors: ACVR1A | ACVR1B | ACVR1C | ACVRL1 | BMPR1A | BMPR1B | TGFBR1 | |
| Signal transducers: SMAD1 | SMAD2 | SMAD3 | SMAD4 | SMAD5 | SMAD6 | SMAD7 | SMAD9 | |
| Ligand Inhibitors: Cerberus | Chordin | DAN | Decorin | Follistatin | Gremlin | Lefty | LTBP1 | Noggin | THBS1 | |
| Coreceptors: BAMBI | Cripto Other: SARA |
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