Filaggrin

From Wikipedia, the free encyclopedia

Filaggrins are filament-associated proteins which bind to keratin fibers in epidermal cells. Mutations in the gene coding for filaggrin result in dry skin (ichthyosis vulgaris) and strongly predispose to eczema. Scientists hope to develop treatments for eczema through their newfound knowledge of filaggrin.

[edit] See also

• Keratohyalin

[edit] External links

• L J McKinley-Grant, W W Idler, I A Bernstein, D A Parry, L Cannizzaro, C M Croce, K Huebner, S R Lessin, and P M Steinert. Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.Proc Natl Acad Sci U S A. 1989 July; 86(13): 4848–4852.
• Nigel Hawkes Gene discovered offers hope for eczema and asthma sufferers. The Australian. 20 March 2006.
• [Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis [1]]