Wikipedia:Featured article candidates/Cell nucleus
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[edit] Cell nucleus
This A-class article was the subject of the molecular and cellular biology collaboration in September, and was barely more than a stub before we started work. Much of the credit for the work and collaboration coordination goes to ShaiM, who is currently on a break, with contributions from myself and many members of the MCB project. The article had a brief peer review in October, archived here. Comments on this critical article in cell biology would be appreciated. Thanks. Opabinia regalis 03:49, 15 December 2006 (UTC)
- Support, for what it's worth. I'm admittedly biased, but we worked hard on this to make it into what it is, and I'm satisfied that it's complete. – ClockworkSoul 04:03, 15 December 2006 (UTC)
- Support. A shorter version of the lede will have to be created for it to go on the front page. I'm sure you guys are working on this. Samsara (talk • contribs) 12:19, 15 December 2006 (UTC)
- There are three 2-3 sentence sections in the middle of the article. It's not clear why they need their own section headers. Otherwise, good. Christopher Parham (talk) 16:37, 15 December 2006 (UTC)
- Comments
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- In the introduction, its not clear what this means "It was later popularized by Scottish botanist Robert Brown in 1831." When was the cell nucleus ever popular? :)
- Units of measurement should be spelled out on first use Style guide (such as μM)
- Are all Karyopherins really transcription factors? "Most proteins, ribosomal subunits, and some RNAs are transported through the pore complexes in a process mediated by a family of transcription factors known as karyopherins."
- Need to stick to either US or real English. I caught a few British spellings and changed them to US English, since this seems to predominate.
- The changes in sub-cellular localisation of Hexokinase seems to have more to do with transcriptional control than direct control of enzyme activity, see review in PMID: 12007644 "The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiae." Moreno F, Herrero P. After all, phosphorylated hexoses will diffuse freely in and out of the nucleus.
- I can't find any references in PubMed to nuclear laminins regulating apoptosis. "The progressive organisation of the nuclear lamina throughout apoptosis is used to initiate and regulate the various phases of apoptosis." TimVickers 17:56, 15 December 2006 (UTC)
