Famciclovir


Famciclovir
Systematic (IUPAC) name
[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate
Identifiers
CAS number	104227-87-4
ATC code	J05 AB09 S01 AD07
PubChem	3324
DrugBank	APRD00600
Chemical data
Formula	C₁₄H₁₉N₅O₄
Mol. weight	321.332 g/mol
Physical data
Melt. point	103 °C (217 °F)
Pharmacokinetic data
Bioavailability	75–77%
Protein binding	20-25%
Metabolism	Hepatic, circulation, intestinal wall (to penciclovir)
Half life	2–2.3 hours
Excretion	Renal, faecal
Therapeutic considerations
Pregnancy cat.	B1 (Au), B (U.S.)
Legal status	S4 (Au), POM (UK), ℞-only (U.S.)
Routes	Oral

Famciclovir (INN) (IPA: [pɛnˈsaɪklovir]) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).

In Korean it is sold under the brand name 팜시바 with the generic name of 팜시클바.

[edit] See also

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Anti-herpesvirus agents		Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine
Anti-influenza agents		Amantadine, Oseltamivir, Peramivir, Rimantadine, Zanamivir

Antiretroviral drugs	NRTIs	Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine
	NtRTIs	Tenofovir
	NNRTIs	Efavirenz, Delavirdine, Nevirapine
	PIs	Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir
	Fusion inhibitors	Enfuvirtide

Other antiviral agents		Adefovir, Fomivirsen, Imiquimod, Inosine,Interferon, Podophyllotoxin, Ribavirin, Viramidine