Entner-Doudoroff Pathway
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The Entner-Doudoroff pathway describes a series of reactions that catabolize glucose to pyruvate using a different set of enzymes from those used in either glycolysis or the pentose phosphate pathway. This pathway can occur only in prokaryotes. Most bacteria use glycolysis and the pentose phosphate pathway. There are a few bacteria that substitute glycolysis with the Entner-Doudoroff Pathway. Distinct feature of Entner-Doudoroff pathway is that it uses 6-phosphogluconate dehydrase and 2-keto-3-deoxyglucosephophate aldolase to create pyruvates from glucose. Microorganisms of this specie does not produce gases during its metabolic process, distinguishing them from microorganisms of enteric specie.
Glycolysis has a net yield of 2 ATP for every one glucose molecule processed. The Entner-Doudoroff Pathway has a net yield of 1 ATP for every glucose molecule processed, as well as 1 NADH and 1 NADPH.
The gram-negative Pseudomonas aeruginosa and the gram-positive Enterococcus faecalis utilizes the Entner-Doudoroff Pathway. Other gram-negative bacteria that use this pathway are Azotobacter and Rhizobium.
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Refereces Mohamed, M. Optometry Professor. Smith, K. Optometrist. Sohn, S. Biomedical Science Professor.
