Enoyl-CoA hydratase
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Enoyl-CoA hydratase is the enzyme used to catalyze the second step of β-oxidation in Fatty acid metabolism. It catalyzes the following reaction:
The reaction hydrates the bond between C-2 and C-3 on trans-Δ2-enoyl-CoA. The end-product is L-3-Hydroxyacyl CoA.
The reaction is a stereospecific syn-addition of water to a double bond, forming the L-isomer. The enzyme will also catalyze the hydration of a cis bond, as found in unsaturated fatty acids, but the isomer formed is then a D-isomer, which is not a substrate for the following steps of Fatty acid metabolism.
The enzyme is mechanistically similar to fumarase.
It is classified as EC 4.2.1.17.
[edit] References
Lehninger Principles of Biochemistry, 4th ed. edited by Nelson and Cox.
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