Enflurane

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Enflurane
Systematic (IUPAC) name
2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethane
Identifiers
CAS number	13838-16-9
ATC code	N01AB04
PubChem	3226
DrugBank	APRD00234
Chemical data
Formula	C3H2ClF5O
Mol. weight	184.492 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	97%
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Enflurane (2-chloro-1,1,2,-trifluoroethyl-difluoromethyl ether) is a halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s. Developed by Ross Terrell in 1963, it was first used clinically in 1966.

Enflurane is a structural isomer of isoflurane. It vaporizes readily, but is a liquid at room temperature.

Clinically, enflurane produces a dose-related depression of myocardial contractility with an associated decrease in myocardial oxygen consumption. Between 2% and 5% of the inhaled dose is oxidised in the liver, producing fluoride ions and difluoromethoxy-difluoroacetic acid. This is significantly higher than the metabolism of its structural isomer isoflurane.

[edit] Physical properties

Molecular weight	184.5 g/mol
Boiling point (at 1 atm):	56.5 °C
MAC :	1.68
Vapor pressure:	172 mmHg	(at 20°C)
Blood:Gas Partition Coefficient:	1.9
Oil:Gas Partition Coefficient:	98

[edit] External links

• Links to external chemical sources.

General anesthetics (N01A) edit
Ethers:	Diethyl ether, Vinyl ether, Desflurane, Enflurane, Isoflurane, Methoxyflurane, Sevoflurane
Haloalkanes:	Chloroform, Halothane, Trichloroethylene
Barbiturates:	Hexobarbital, Methohexital, Narcobarbital, Thiopental
Opioids:	Alfentanil, Anileridine, Fentanyl, Phenoperidine, Remifentanil, Sufentanil
Others:	Alfaxalone, Minaxolone, Droperidol, Esketamine, Etomidate, Hydroxybutyric acid, Ketamine, Nitrous oxide, Propanidid, Propofol, Xenon