Talk:Eicosanoid
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[edit] Accuracy
This article is a very good piece of work and shows a lot of research. But let me offer a correction. It repeatedly states that all eicosanoids are derived from arachadonic acid. This is incorrect.
- The series-2 prostaglandins (PG) and thromboxanes (TX) are derived from arachadonic acid.
- The series-1 PG and TX are derived from Gamma-linolenic acid through the DGLA intermediary.
- The series-3 PG and TX are derived from EPA.
I'm not sure about the prostacyclins and the leukotrienes. Also, arachadonic acid has other uses in the body besides eicosanoids, e.g. as a substrate for the endocannabinoids. David Throop 25 Oct 2005
Also, the article states that the eicosanoids are a class of cytokines. But the cytokine article says that cytokines are proteins. And eicosanoids aren't proteins; they don't even have any nitrogen in their structure.
David Throop 13 Nov 2005
[edit] EETs
I think that there is a third way of arachidonic acid metabolism, called epoxygenase.
- Yes, there is, the EETs, via the Cytochrome P450 path. I'd noted it but haven't read enough about it to say anything interesting. I've added a link for it, but there's nothing there yet. I also added a link to a future article on Neuroprotectin D, which is AA derived. Does anybody know more about the EETs? Particularly, does anybody know if they only come from AA, or is there an EPA derived subfamily for them too?David.Throop 15:02, 12 March 2006 (UTC)
[edit] General discussion
This page looks good. I've never studied this topic, so there's not much that I can say about it. It might be nice to add some diagrams of molecular structures. I know that Canvas is a good program for this, but I won't be able to draw them any time soon. Do you know anything about the receptors for these hormones? I'm going on a Wiki-vacation, so I won't be available for more input for a while. Keep up the good work! AdamRetchless 08:15, 4 May 2004 (UTC)
- My source has quite a bit on the receptors, but they are quite specific for leukotrienes, prostacyclin etc. I thought it would be better to include this in the related articles, rather than on eicosanoid proper.
JFW | T@lk 09:28, 4 May 2004 (UTC)
I just wanted to say, completely out of place really, that I am totally in awe of whoever made that brilliant diagram with all the links in it. People like you are exactly what the world needs more of. Wikipedia just blows me away.
[edit] Grammar
Is "that largely function as a autocrine and" supposed to refer to a chemical known as "a autocrine"? Perhaps it should be in italics -- it looks like a grammar error, but I am not sure if it is one. Cleduc 1 July 2005 19:46 (UTC)
[edit] Cleanup
Someone asked for cleanup, because:
This article is a very good piece of work and shows a lot of research. But let me offer a correction. It repeatedly states that all eicosanoids are derived from arachadonic acid. This is incorrect. The series-2 prostaglandins (PG) and thromboxanes (TX) are derived from arachadonic acid. The series-1 PG and TX are derived from Gamma-linoleic acid through the DGLA intermediary. The series-3 PG and TX are derived from EPA. I'm not sure about the prostacyclins and the leukotrienes. Also, arachadonic acid has other uses in the body besides eicosanoids, e.g. as a substrate for the endocannabinoids.
- This is not good use of cleanup. Cleanup is when the fact are correct but presented clumsily. If you think the facts are incorrect, fix it! JFW | T@lk 20:51, 26 October 2005 (UTC)
[edit] References?
This article seems to be more or less accurate, but it needs to be properly referenced.--Virulent 78 13:49, 4 February 2006 (UTC)
- I'll find a few, but with M.W. King's site linked I guess we don't need the {{unreferenced}} template anymore. JFW | T@lk 05:16, 5 February 2006 (UTC)
