Talk:ECA stack

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Ephedrine acts to increase energy by its actions as a symptomimetic amine. It increases dopamine and noradrenaline levels in the brain, and also serves as a dopamine reuptake inhibitor.

Is ephedrine really a dopamine reuptake inhibitor?

-- Yes, AFAIK, all phenethylamines are due to the related uptake action for dopamine, adrenaline, and noradrenaline. As ephedrine binds at noradrenaline receptors that also transport dopamine, the effect is less than cocaine or amphetamine, but still seems to be present. I've included two references that should help clarify this.


Ok, answered my own questions here. The thermogenic effect is ultimately due to the action of the noradrenaline, rather than any direct effect of the ephedrine on beta-3 receptors, as l-ephedrine, the kind sold OTC, has little beta-3 agonist activity.

I emailled Dr. Wellman, author of the study comparing various stimulants' thermogenic properties in human BAT. Unfortunately, while this study is not fully available online (just the abstract), he told me the results were that d-pseudoephedrine had three times less thermogenic activity as l-ephedrine.

I assume that ephedrine increases the body temperature by 2 degrees Fahrenheit, but shouldn't this be spelled out?

Ephedrine was NEVER banned in the United States, Ephedra was. I think it is important to make this distinction in the article. The stack was most commonly "built" with Ma Hung or similar standardized for 25mg ephedrine alkaloids. The ban was for supplements on dietary supplements containing ephedrine alkaloids. Volksgeist 14:47, 26 March 2006 (UTC)

I've made a couple small changes to the page. Ephedrine was never banned and can legally be purchased with (or without) an expectorant. For example D&E Pharm sells pure Ephedrine HCL, although you must show ID to purchase. Ephedrine has always been able to be legally purchased OTC in products such as Bronchaid. Many companies that sell "bodybuilding" products started selling Ephedrine HCL (with an expectorant) -- such as VasoPro and BioTek. Although the ephedra ban was lifted I've seen very few products still being sold that contain ephedra alkaloids (most likely because of the fear of lawsuits). Volksgeist 14:54, 26 March 2006 (UTC)

[edit] fahrenheit/celsius?

I assume that ephedrine increases the body temperature by 2 degrees Fahrenheit, but shouldn't this be spelled out?

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