Dupuytren's contracture

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**Dupuytren's contracture**
*Classifications and external resources*
ICD-10	M72.0
ICD-9	728.6
OMIM	126900
DiseasesDB	4011
MedlinePlus	001233
eMedicine	med/592 orthoped/81 plastic/299 pmr/42 derm/774

Dupuytren's contracture of the fourth digit (ring finger).

Dupuytren's contracture (also known as Morbus Dupuytren) is a fixed flexion contracture of the hand where the fingers bend towards the palm and cannot be fully extended (straightened). It is named after the famous surgeon Baron Guillaume Dupuytren, who described an operation to correct the affliction.

The ring finger and little finger are the fingers most commonly affected; the middle finger may be affected in advanced cases, but the index finger is nearly always spared. The thumb is never involved. Dupuytren's contracture progresses slowly and is usually painless. In patients with this condition, the tissues under the skin on the palm of the hand thicken and shorten so that the tendons connected to the fingers cannot move freely. The palmar aponeurosis becomes hyperplastic and undergoes contracture. As a result, the affected fingers start to bend more and more and cannot be straightened.

Incidence increases after the age of 40; at this age men are affected more often than women. After the age of 80 the distribution is about even.

1 Symptoms
2 Risk Factors and Possible Causes
3 Treatment
4 External links

[edit] Symptoms

In Dupuytren's disease, the tough connective tissue within one's hand becomes abnormally thick, which can cause the fingers to curl, and can result in impaired function of the fingers, especially the small and ring fingers. It usually has a gradual onset, often beginning as a tender lump in the palm. Over time, pain associated with the condition tends to go away, but tough bands of tissue may develop. [1] These bands, which are the source of the reduced mobility commonly associated with the condition, are visible on the surface of the palm, and may appear similar to a small callus. It commonly develops in both hands, and has no connection to dominant- or non-dominant hands, nor any correlation with right- or left-handedness.

The contracture sets on very slowly, especially in women. However, when present in both hands, and when there is associated foot involvement, it tends to accelerate more rapidly.

[edit] Risk Factors and Possible Causes

Regular operation of heavy machinery increases one's risk of developing Dupuytren's contracture; family history, diabetes, liver disease, alcoholism, epilepsy and pulmonary tuberculosis are also factors. Surgery of the hand may trigger growth of Dupuytren nodules and cords if an inclination existed before. Dupuytren's contracture may accompany fibrosing syndromes such as Peyronie's disease, Ledderhose's disease and Riedel's struma.

Those of northern European descent are markedly at risk. Margaret Thatcher is perhaps the most famous patient. Interestingly, although this a predominantly caucasian disease, many Caribbean blacks can present with contractures, and all can trace a distant relative to England or Ireland.

Dupuytren's disease is a very specific affliction, and primarily affects:

People of Scandinavian or Northern European ancestry[2], particularly those of Viking descent[3].
Men rather than women (Men are ten times as likely to develop the condition)[4]
People over the age of 40, and
People with a family history (60 to 70% of those afflicted have a genetic predisposition to Dupuytren's Contracture)[5]

Correlations have also been found between Dupuytren's contracture and:

Smoking or drinking activity,
Diabetes, Thyroid problems and Epilepsy
Alcoholism and Liver Disease

There is also some speculation that Dupuytren's may be caused by physical trauma, such as manual labor or other over-exertion of the hands. However, the fact that Dupuytren's is not connected with handedness casts some doubt on this claim. [6]

[edit] Treatment

Surgery (in cases of severe contracture removes the contracture)
Radiation therapy (specifically in early stages inhibits development of contracture)
Needle aponevrotomy (releases the contracture)
Triamcinolone (kenalog) injections provide some relief

Surgical management consists of opening the skin over the affected cords of fibrous tissue, and dissecting the fascia away. The tendons can then be brought out to length. The procedure is not curative, and patients may need re-do surgery, however, the thickened fascia often invests the digital nerves and arteries, so there is significant risk of de-vascularization of the digit.

Treatment of Dupuytren's disease with low energy x-rays (radiotherapy) may cure Morbus Dupuytren on a long term, specifically if applied in early stages of the disease. Needle aponevrotomy is a minimal invasive technique where the cords are weakened through the insertion and manipulation of a small needle. Once weakened, the offending cords may be snapped by simply pulling the finger(s) straight. The nodules are not removed and might start growing again. Currently in phase III of Food and Drug Administration (FDA) approval is another promising therapy, the injection of collagenase. This procedure is similar to needle aponevrotomy, however the chords are weakened through the injection of small amounts of an enzyme that dissolves them.

Dupuytren's Contracture is not a dangerous condition, and oftentimes no treatment is necessary. Even when treatment is used, there is no permanent way to stop or cure the infliction. If there is a painful lump present, an injection can often help alleviate the pain. If pain persists or the funcion of the hand becomes seriously impaired, individuals often choose to have surgery. This surgery usually entails removing or separating the thickened bands, and is unlikely to cause any major complications or side effects, although in serious cases, some minor skin grafting may be necessary. Any damaged skin or tissue in the surgically affected area of the hand will heal fairly quickly, and reducing bloodflow during the healing period helps reduce pain. This may be done by keeping the hand raised or elevated so that blood does not pool in the affected area.

After surgical treatment, the condition may re-develop more rapidly than before.