Dorzolamide
From Wikipedia, the free encyclopedia
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Dorzolamide
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| Systematic (IUPAC) name | |
| 2-ethylamino-4-methyl-5, 5-dioxo-5$l^{6}, 7-dithiabicyclo[4.3.0] nona-8,10- diene-8-sulfonamide | |
| Identifiers | |
| CAS number | 130693-82-2 120279-96-1 |
| ATC code | S01EC03 |
| PubChem | 3154 |
| DrugBank | APRD00577 |
| Chemical data | |
| Formula | C10H16N2O4S3 |
| Mol. weight | 324.443 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | ~33% |
| Metabolism | ? |
| Half life | 4 months |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Dorzolamide is a carbonic anhydrase inhibitor.
Trusopt (dorzolamide hydrochloride ophthalmic solution) is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Trusopt is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
[edit] References
- Plummer C, MacKay E, Gelatt K. "Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.". Vet Ophthalmol 9 (4): 245-9. PMID 16771760.
- Grover S, Apushkin M, Fishman G (2006). "Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.". Am J Ophthalmol 141 (5): 850-8. PMID 16546110.
- Almeida G, Faria e Souza S (2006). "Effect of topical dorzolamide on rabbit central corneal thickness.". Braz J Med Biol Res 39 (2): 277-81. PMID 16470316.
[edit] External links
| Antiglaucoma preparations and miotics (S01E) edit | ||
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| Sympathomimetics: |
Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine |
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| Parasympathomimetics: |
Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine |
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| Carbonic anhydrase inhibitors: |
Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide |
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| Beta blocking agents: |
Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol |
|
| Prostaglandin analogues: |
Bimatoprost, Latanoprost, Travoprost, Unoprostone |
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| Other agents: |
Dapiprazole, Guanethidine |
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