Dobutamine

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Dobutamine
Systematic (IUPAC) name
4-[2-[3-(4-hydroxyphenyl)-1-methyl-propyl] aminoethyl]benzene-1,2-diol
Identifiers
CAS number	34368-04-2
ATC code	C01CA07
PubChem	36811
DrugBank	APRD00122
Chemical data
Formula	C18H23NO3
Mol. weight	301.38 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	2 minutes
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Dobutamine is a beta-1 adrenergic agonist. It is a direct-acting agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptors to induce the release of norepinephrine (an alpha-1 agonist), dobutamine is less prone to induce hypertension than dopamine. Chronotropic, arrhythmogenic, and vasodilative effects are negligible. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility, which could be the result of either organic heart disease or cardiac surgical procedures.

Adrenergic and dopaminergic agents (C01CA)edit
	Dobutamine, Dopamine, Epinephrine, Fenoldopam, Isoprenaline, Metaraminol, Midodrine, Norepinephrine, Octopamine, Phenylephrine