DNA sequencer
From Wikipedia, the free encyclopedia
A DNA sequencer is a machine to automatize the DNA sequencing process.
In time of big genomes projects, to enhance human productivity is important.
Modern automated DNA sequencing instruments (called DNA sequencers) are able to sequence as many as 384 fluoresecently labelled samples in a batch (run) and perform as many as 24 runs a day. These perform only the size separation and peak reading; the actual sequencing reaction(s), cleanup and resuspension in a suitable buffer must be performed separately.
The magnitude of the fluorescent signal is realated to the number of strands of DNA that are in the reaction. If the initial amount of DNA is small, the signals will be weak. However, the properties of PCR allow one to increase the signal by increasing the number of cycles in the PCR programme.
