Disodium aurothiomalate
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| Image:Disodium aurothiomalate.png | |
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Disodium aurothiomalate
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| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | ? |
| Chemical data | |
| Formula | C4H3AuNa2O4S |
| Mol. weight | ? |
| Pharmacokinetic data | |
| Bioavailability | 0% |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | intramuscular injection |
Disodium aurothiomalate is an organogold compound used for its antirheumatic effects to treat rheumatoid arthritis. It is the disodium salt of gold (auro) - thio - succinic acid.
[edit] Mechanism of action
It inhibits lymphocyte proliferation, lysosomal enzyme release, the release of reactive oxygen species from macrophages, and IL-1 production.
Gold salts can decrease the inflammation of the joint lining. This effect can prevent destruction of bone and cartilage. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs
[edit] Side effects
It can also cause photosensitive rashes, gastrointestinal disturbance, and kidney damage.
[edit] See also
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