Dilute Russell's viper venom time
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Dilute Russell's viper venom time (dRVVT) is a laboratory test for lupus anticoagulant (LA). This in vitro diagnostic test is based on the property that the venom of the Russell's Viper is effective at inducing thrombosis. The coagulant in the venom directly activates factor X, which turns prothrombin into thrombin in the presence of factor V and phospholipid. The venom is diluted to give a clotting time of 23 to 27 seconds and the phospholipid is reduced to make the test extremely sensitive to phospholipid. The dRVVT test is more sensitive than the aPTT test for the detection of lupus anticoagulant (an autoimmune disorder), because it is not influenced by deficiencies in clotting factors VIII, IX or XI.[1]
The dRVVT is thought to be more sensitive than the activated partial thromboplastin time (aPTT) for detection of lupus anticoagulants.
[edit] References
- ^ Antiphospholipid Syndrome at SpecialtyLaboratories. Accessed 27 September 2006.
[edit] External links
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