Diethylcathinone

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Diethylcathinone chemical structure
Diethylcathinone
Systematic (IUPAC) name
2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number 134-80-5
ATC code  ?
PubChem 7029
Chemical data
Formula C13H19NO 
Mol. weight 241.76
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

B
Legal status

DEA Schedule IV
Routes  ?

Diethylcathinone, also called Diethylpropion, is a sympathomimetic stimulant drug marketed as an appetite suppressant.

The popular antidepressant, Wellbutrin (bupropion) is a derivative of this chemical. Both diethypropion and bupropion have a stimulant effect on the CNS.

Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl analog of cathinone and dimethylcathinone. Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate®, Tepanil Ten-Tab®). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

Contents

[edit] Contraindications:

  • Hypersensitivity to sympathomimetic amines
  • Advanced arteriosclerosis or symptomatic cardiovascular disease
  • Moderate or severe hypertension
  • Hyperthyroidism
  • History of drug abuse
  • MAO inhibitor use (within 14 days)

[edit] Side effects:

[edit] Severe:

  • Pulmonary hypertension
  • Stroke
  • Psychosis

Cardiovascular:

  • Tachycardia, hypertension, arrhythmia, chest pain

Ear, nose, and throat:

  • Xerostomia, metallic taste

Endocrine:

  • Changes in libido, gynecomastia, menstrual irregularities

Eye:

  • Blurred vision

Gastrointestinal:

  • Nausea/vomiting, constipation, abdominal cramps

Hematological:

  • Bone marrow depression, agranulocytosis, leukopenia

Neurological:

  • Tremor

Psychological:

  • Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures

Skin:

  • Rash, hives, alopecia, ecchymosis

Urogenital and reproductive:

  • Changes in libido, impotence

[edit] See also

[edit] References


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