Diethylcarbamazine
From Wikipedia, the free encyclopedia
 |
|
|
Diethylcarbamazine
|
|
| Systematic (IUPAC) name | |
| 4-methyl-N,N-bis (4-methylpiperazin-2-yl)- piperazine-1-carboxamide | |
| Identifiers | |
| CAS number | 90-89-1 |
| ATC code | P02CB02 |
| PubChem | 3052 |
| DrugBank | APRD00918 |
| Chemical data | |
| Formula | C10H21N3O |
| Mol. weight | 199.293 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Diethylcarbamazine (DEC) (C10H21N3O) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements. DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia; and loiasis. DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the treatment of dog heart worm Dirofilaria immitis.
[edit] Trade names
- Hetrazan
- Carbilazine
- Caricide
- Cypip
- Ethodryl
- Notézine
- Spatonin
- Filaribits
- Banocide Forte
 |
This medical treatment article is a stub. You can help Wikipedia by expanding it. |
DEC is an inhibitor of Aracadonic acid metabolism in filarial mf. This makes the mf more susceptible to immune attack.
