Talk:Dextroamphetamine

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[edit] Literature

"Dexedrine" is also mentioned in Fleming's "Goldfinger". It was distributed on the train before the raid on Fort Knox.

Greetings,

I'm trying my best to throw in some contributions about this (and other) fascinating things here on Wikipedia but haven't seen any obvious ways to upload/link to further graphics which I have w/o replacing the one at the head of the article, which I'd rather not do.

If you search for

Dexedrine Spansule

In the images section, you'll see the image I'm referring to; I uploaded it before, but it was deleted due to my not having stated more explicitly that I was the creator (and therefore sole owner of copyright, and able to transfer same). I've re-uploaded it, and hopefully made it clearer as to its origin.

Further images may be found at http://www.dextroamphetamine.net/ - I suppose, worst case, I can simply link to the graphics on my site from here. I'm not averse to that, though am not trying to contravert anything on Wikipedia in any way if they're averse to externally linked graphics....

Anyone, please advise. I'll upload more as time permits.


~RTF~ Rtf 17:44, 28 April 2006 (UTC)

[edit] Methamphetamine mention? also: half-life?

Curious about this paragraph: Although amphetamine derivatives are outside the scope of this article, it is the dextrorotary enantiomer of amphetamine to which the addition of a methyl group yields d-methamphetamine, the most active stereoisomer of methamphetamine. The methyl group also increases the length that the stimulant's effects are present, presumably because methamphetamine is metabolized to amphetamine. Curiously enough, that the duration of the drug is elevated by the addition of the methyl group, various studies[citation needed] appear to indicate that the increase in potency isn't actually by that much, if at all; this remains unverified, however, so the operational assumption is that the potency is increased as well.

I edited it a little, but I started wondering: does it need to be kept? It seems pretty intuitive that d-methamphetamine is d-amphetamine plus a methyl group, and I don't think d-amphetamine is commonly used to make meth anyway: methamphetamine doesn't mention it, and making Schedule II drugs from Schedule II drugs strikes me as kind of silly. Even if that were worth keeping, the rest is just about methamphetamine's effects relative to amphetamine. That information is already covered in the methamphetamine article, and I don't think it's particularly relevant here. Plus, the actual science is questionable in both revisions (in the original because the half-life information is clearly contradicted elsewhere, in the current because I wrote it and it is thus suspect). Opinions?

Also, is 28 in "10-28 hours" maybe a little on the high side? I'm sure it can go that high or higher in poor metabolizers (defective CYP2D6 is uncommon, but not rare), but it can go lower too in ultra-rapid metabolizers... either way, surely not typical. Am I missing something or several somethings? SVI 16:40, 25 May 2006 (UTC)

It's been a week or so, so I'm assuming there are no objections to removing the meth paragraph. Just took it out now. I'll leave half-life to someone more knowledgeable about the relevant pharmacokinetics, though. SVI 06:52, 3 June 2006 (UTC)
I believe that the reason the half-life has such a wide range is that it can vary widely even within the same person. In addition to being metabolized, d-amph can also be excreted unchanged in urine. But that route is strongly dependent on urinary pH, which is in turn strongly dependent on what the person ate and drank in the preceding several hours. The 28 hour figure sounds about right for the case of alkaline urine where 95%+ of the elimination is due to metabolism rather than excretion. 69.21.93.150 23:19, 11 July 2006 (UTC) Konrad
Hi - Sorry I didn't respond to you sooner, but current events & work have kept me occupied for the present....In any case, I included the above information for no other reason than to *be* encyclopedic: yes, you are correct, it *is* obvious that d-methamphetamine is d-amphetamine + a methyl group....Just as it is obvious to you or I what the prefixes of d- and l- stand for. As I know for a fact there are people in existence so dim I wouldn't let them operate a VCR much less a computer, it stands to reason that there are probably those operating computers and accessing the Internet who are not, to put it kindly, Chemical Wizards or remotely close to understanding their native language, much less anything nearing Jargon specific to a given scientific field; hence the extended explanation.
That said, I have no problems with your removal of it; hell, *I* am far to lazy to edit myself, so I can only thank you (honestly) for taking the time to do it for me. My point there was actually that (contrary to popular belief) there really isn't much in the way of proof that 'Meth' is any stronger than Dexedrine; on the contrary, there are studies indicating otherwise, with the subjects unable to tell the difference, even. That I cannot cite the precise time/date/place/name/research groups involved with some studies I read about some time ago *does* render these facts (I suppose) inadmissible, in a technical sense, so I don't have much room to argue the point; in short, no disagreements from I. RTF

[edit] Clinical Usage: Indications

The language in the Clinical Usage section is mixing medical issues with legal ones. In the case of the US, the FDA decides approval, while the medical community decides indications. The phrases "accepted indications" or "non-approved inidications" are mixing up the two. *Any* drug can be prescribed for *any* indication as long as it's approved for some use.

69.21.93.150 23:19, 11 July 2006 (UTC) Konrad

[edit] Agenda

Here are some changes I'm planning to make to the article. Comments and suggestions are welcome. (Finished items are crossed out. KonradG 18:40, 11 September 2006 (UTC))

  • Split history & overview into seperate sections. Perhaps put back some of the regulatory stuff I deleted.
  • Add info about DA mediating reward effect and NE mediating anorectic effect. (Find ref on the Tyrosine depletion experiments that show this)
  • Add some discussion on acute tolerance. Subjective effects vs plasma concentrations. Ideally find some direct data comparing AMP to other stimulants in this regard.
  • Mention subjective effects begin more slowly because of BBB
  • LD50 in rats, lowest known fatal doses in humans
  • Explain amphetamine psychosis
  • Add other CYP450 enzyme responsible for conversion to hydroxyamphetamine
  • (New item Sept 12) Saw several mentions of half-life in children being as low as 6 hours! Find refs and update half-life info.

KonradG 12:52, 8 September 2006 (UTC)

Anyone know to properly cite a quote from a book? I temporarily put a link to a website referring to "The Pharmacological Basis of Therapeutics", but I'd like to make the cite specific to page 553 of the 7th edition. KonradG 18:36, 11 September 2006 (UTC)

[edit] Note about anti sea-sickness use

Experiment Description for: Inflight Salivary Pharmacokinetics of Scopolamine and Dextroamphetamine (DSO 457)

http://lsda.jsc.nasa.gov/scripts/experiment/exp_descrp_pop_up.cfm?exp_id=DSO%20457&string=&current_string=

Scopolamine/dextroamphetamine, a drug combination used to prevent motion sickness, was studied because of its frequent use by crewmembers during flight and its reportedly variable pharmacokinetics and poor bioavailability on the ground.

--Charles Gaudette 19:40, 8 September 2006 (UTC)

[edit] Dexatrim

A new Wikipedian, Uncwfu2, recently tried to add Dexatrim to the article. I mildly agree with the revert. I want to throw some notes into the talk page about Dexatrim just to get them journaled; especially as at this time there is no article about Dexatrim on Wikipedia (that I could find). KonradG stated in his revert that: "Dexatrim is phenylpropanolamine, not d-amphetamine". That was true, but Dexatrim has switched (by the account I could find) to ephedrine. It seems to me that the name "Dexatrim" was deliberately devised because the marketers: (1) wanted to link themselves to, or (2) wish they could actually use, dextroamphetamine. If that conjecture can be factually made with a credible reference, then Dexatrim may very well have a place in the popular culture section. --Charles Gaudette 21:18, 4 October 2006 (UTC)

According to their site, Dexatrim used to contain ephedrine but doesn't any more. I reverted the addition because I thought it was the result of someone confusing the two chemicals. If the intent was to clarify that Dexatrim is *not* d-amphetamine, I see no problem with putting it back. KonradG 01:10, 5 October 2006 (UTC)

My first edit as a Wikipedian was intended to point out the similarity in nomenclature between Dexatrim and Dexadrine. I now realize that this was a poor attempt at making the connection. Thanks for the dialog and feedback.

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