Dextrorphan

From Wikipedia, the free encyclopedia

You have new messages (last change).

Dextrorphan (DX) is a pharmacologically active metabolite of dextromethorphan (DM, DXM).

[edit] Chemistry

It is the result of O-demethylation of the prodrug by several enzymatic systems, although it is chiefly a product of the Cytochrome P450 IID6 (CYP4502D6) pathway.

[edit] Pharmacology

Being structurally similar to dextromethorphan, and it has affinity for the same receptors in the central nervous system but with a slight difference in selectivity.

Dextromethorphan is a weak non-competitive NMDA receptor antagonist but dextrorphan is a more potent antagonist[1]. DX is a strong anti-tussive[citation needed], but is slightly less effective than DM, and has no metabolites with significant therapeutic activity in such capacity and therefore is not a drug available on the market.

[edit] See also


 This biochemistry article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org../../../d/e/x/Dextrorphan.html"
In other languages