Darifenacin

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Darifenacin chemical structure
Darifenacin
Systematic (IUPAC) name
2-[1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl] pyrrolidin-3-yl] -2,2-diphenyl-acetamide
Identifiers
CAS number 133099-04-4
ATC code G04BD10
PubChem 444031
DrugBank APRD00903
Chemical data
Formula C28H30N2O2
Mol. weight 426.55 g/mol
Pharmacokinetic data
Bioavailability 15 to 19% (dose-dependent)
Protein binding 98%
Metabolism Hepatic (CYP2D6- and CYP3A4-mediated)
Half life 13 to 19 hours
Excretion Renal (60%) and biliary (40%)
Therapeutic considerations
Pregnancy cat.

B3(AU) C(US)

Legal status

-only(US)

Routes Oral

Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence.

Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate. It should not be used in people with urinary retention.

[edit] Administration

Darifenacin is administered as a once-daily extended-release oral tablet.

[edit] Side effects


Urologicals (G04) edit
Acidifiers:

Ammonium chloride, Calcium chloride

Urinary antispasmodics:

Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium

For erectile dysfunction:

Alprostadil, Apomorphine, Moxisylyte, Papaverine, Phentolamine, Sildenafil, Tadalafil, Vardenafil, Yohimbine

Other urologicals:

Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Phenazopyridine, Phenyl salicylate, Succinimide

For benign prostatic hypertrophy:

5α-reductase inhibitors: Dutasteride, Finasteride
Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin
Herbals: Pygeum africanum, Serenoa repens