DARPP-32

From Wikipedia, the free encyclopedia

DARPP-32 stands for dopamine- and cyclic AMP-regulated phosphoprotein with molecular weight 32 kDa.

It was discovered by Paul Greengard and co-workers.

DARPP32 is related to dopamine [1], glutamate and adenosine; and may be related to schizophrenia [2], Parkinson's disease or EPS (Extra-pyramidal symptoms).

A considerable proportion of the psychomotor effect of cannabinoids can be accounted for by a signaling cascade in striatal projection neurons involving PKA-dependent phosphorylation of DARPP-32, achieved via modulation of dopamine D2 and adenosine A2A transmission [3].

Currently there are strong evidences that DARPP-32 may be the shared chain in the action of multiple drugs including cocaine, amphetamine, nicotine, caffeine, LSD, PCP, ethanol and morphine [1]

[edit] External links

[edit] References

  1. ^ Svenningsson P, Nairn AC, Greengard P. DARPP-32 Mediates the Actions of Multiple Drugs of Abuse. AAPS Journal. 2005; 07(02): E353-E360. DOI: 10.1208/aapsj070235 free text
 This science article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org../../../d/a/r/DARPP-32_6378.html"
In other languages