From Wikipedia, the free encyclopedia
Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting activated factor X (factor Xa). Danaparoid is considered a "low molecular weight heparin" but is chemically distinct from heparin and thus has little cross-reactivity in heparin-intolerant patients. It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery. It is also used as a heparinoid substitute in heparin-induced thrombocytopenia which may otherwise cause paradoxical thrombosis. This drug is no longer marketed in the United States.
[edit] Administration
IV
[edit] Side effects
- Bleeding problems
- Low platelets, due to a low level of structural similarity between danaparoid and heparin
- Asthma exacerbations, due to allergies to sulphites contained within the medicine
| Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01) edit |
| Vitamin K antagonists: |
Acenocoumarol, Clorindione, Dicumarol (Dicoumarol), Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
|
Heparin group (Platelet
aggregation inhibitors): |
Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin
|
Other Platelet
aggregation inhibitors: |
Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal
|
| Enzymes: |
Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase
|
| Direct thrombin inhibitors: |
Argatroban, Bivalirudin, Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran
|
| Other antithrombotics: |
Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban
|
| Non-medicinal: |
Citrate, EDTA, Oxalate
|
