CYP2E1
From Wikipedia, the free encyclopedia
Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are some important drug interactions mediated by CYP2E1.
[edit] CYP2E1 Ligands
| Selected inducers, inhibitors and substrates of CYP2E11 | |
| Type | Agent |
| inducers | acetone, ethanol, isoniazid |
| inhibitors | cimetidine, disulfiram, (isoniazid)? |
| substrates | anaesthetics (halothane, isoflurane, etc), dapsone, paracetamol (acetaminophen), theophylline |
Notes:
|
|
|
cytochrome P450, family 2, subfamily E, polypeptide 1
|
|
| Identifiers | |
| Symbol(s) | CYP2E1 CYP2E |
| Entrez | 1571 |
| OMIM | 124040 |
| RefSeq | NM_000773 |
| UniProt | P05181 |
| Other data | |
| Locus | Chr. 10 q24.3-qter |
