CYP1A2

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Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. Expression of CYP1A2 appears to be induced by various dietary constituents (Fontana et al., 1999).

[edit] CYP1A2 Ligands

Selected inducers, inhibitors and substrates of CYP1A21
Type Agent
inducers broccoli, brussel sprouts, chargrilled meat, insulin, modafinil, nafcillin, omeprazole, tobacco, hyperforin (constituent of St Johns Wort)
inhibitors amiodarone, cimetidine, fluoroquinolones (ciprofloxacin, etc), fluvoxamine, interferon, methoxsalen
substrates amitriptyline, caffeine, clomipramine, clozapine, cyclobenzaprine, estradiol, fluvoxamine, haloperidol, imipramine, mexiletine, naproxen, olanzapine, ondansetron, paracetamol, propranolol, riluzole, ropivacaine, tacrine, theophylline, tizanidine, verapamil, warfarin, zileuton, zolmitriptan
Notes:
  1. Where classes of agents are listed, there may be exceptions within the class.

[edit] References

  • Fontana RJ, Lown KS, Paine MF, et al. Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology. 1999 Jul;117(1):89-98. PMID 10381914
  • Meijerman I, et al. Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction. Oncologist. 2006;11:742-52.

[edit] See also

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