CYP1A1

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cytochrome P450, family 1, subfamily A, polypeptide 1
Identifiers
Symbol(s) CYP1A1 CYP1
Entrez 1543
OMIM 108330
RefSeq NM_000499
UniProt P04798
Other data
EC number 1.14.14.1
Locus Chr. 15 q24.1

CYP1A1 is a gene that encodes a member of the cytochrome P450 oxidase superfamily of enzymes. It is involved in lipid and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides; induced by aromatic hydrocarbons. There are 3 main subtypes of CYP1A: M1, M2 and M3.

CYP1A1 and CYP1B1 are regulated by the Aryl hydrocarbon receptor, a ligand activated transcription factor. They are part of the Phase I reactions in drug metabolism.

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