Cycloserine

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Cycloserine chemical structure
Cycloserine
Systematic (IUPAC) name
4-aminoisoxazolidin-3-one
Identifiers
CAS number 68-41-7
ATC code J04AB01
PubChem 401
DrugBank APRD00894
Chemical data
Formula C3H6N2O2
Mol. weight 102.092 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?
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It is oral broad spectrum antibiotic effective against tuberculosis, it inhibits cell wall synthesis of TB bacilli at early stage of peptidoglycan synthesis.

Being trialed for treatment of phobias as well as an adjuvant to conventional treatments for depression and schizophrenia.

Side effects mainly CNS manifestations i.e. headache, irritability, depression, convulsions. Co-administration of pyridoxine can reduce the incidence of some of the CNS side effects(e.g. convulsions).

These psychotropic responses are related to D-cycloserine's action as a partial agonist of the neuronal NMDA receptor for glutamate and have been examined in implications with sensory-related fear extinction in the amygdala. See Michael Davis, Barbara Rothbaum, Kerry Ressler et al. and their work with PTSD at Emory University's School of Medicine. [1]

[edit] References

  1. ^ Picower Institute speakers (2005). "EChange Your Mind: Memory and Disease — Worldwide". MIT World Video Archive.


Antimycobacterials (J04) edit
Tuberculosis:

Aminosalicylic acid, Calcium aminosalicylate, Capreomycin, Cycloserine, Ethambutol, Ethionamide, Isoniazid, Morinamide, Protionamide, Pyrazinamide, Rifabutin, Rifampicin, Rifamycin, Rifapentin, Sodium aminosalicylate, Terizidone, Tiocarlide
Leprosy:

Aldesulfone sodium, Clofazimine, Dapsone
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