Corey-Fuchs reaction

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The Corey-Fuchs reaction is a series of chemical reactions designed to transform an aldehyde into an alkyne.^[1][2][3] The reaction is named after its discoverers, E. J. Corey and P. L. Fuchs.

By suitable choice of base, it is often possible to stop the reaction at the 1-bromoalkyne, a useful functional group for further transformation.

[edit] References

1. ↑  Corey, E. J.; Fuchs, P. L. Tetrahedron Lett. 1972, 36, 3769-3772.
2. ↑  Mori, M.; Tonogaki, K.; Kinoshita, A. Organic Syntheses, Vol. 81, p.1 (2005). (Article)
3. ↑  Marshall, J. A.; Yanik, M. M.; Adams, N. D.; Ellis, K. C.; Chobanian, H. R. Organic Syntheses, Vol. 81, p.157 (2005). (Article)

[edit] See also

• Fritsch-Buttenberg-Wiechell rearrangement
• Seyferth-Gilbert homologation
• Wittig reaction