Cloxacillin

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Cloxacillin
Systematic (IUPAC) name
(2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl- oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Identifiers
CAS number	61-72-3
ATC code	J01CF02
PubChem	6098
DrugBank	APRD00882
Chemical data
Formula	C19H18N3ClO5S
Mol. weight	435.882 g/mol
Pharmacokinetic data
Bioavailability	37 to 90%
Protein binding	95%
Metabolism	?
Half life	30 minutes to 1 hour
Excretion	Renal and biliary
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status
Routes	Oral, IM

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. It is sold under a number of trade names, including Cloxapen® and Orbenin®. Cloxacillin is used against staphylococci that produce beta-lactamase.

This drug has a weaker antibacterial activity than benzylpencillin, and is devoid of serious toxicity except for allergic reactions.

Penicillins (J01C) edit
Amoxicillin, Ampicillin, Azlocillin, Carbenicillin, Cloxacillin, Dicloxacillin, Flucloxacillin, Mezlocillin, Nafcillin, Piperacillin, Pivampicillin, Ticarcillin