Clenbuterol
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Clenbuterol
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| Systematic (IUPAC) name | |
| 1-(4-amino-3,5-dichloro-phenyl)- 2-(tert-butylamino)ethanol |
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| Identifiers | |
| CAS number | 37148-27-9 |
| ATC code | R03AC14 R03CC13 |
| PubChem | 2783 |
| Chemical data | |
| Formula | C12H18N2Cl2O |
| Mol. weight | 277.19 |
| Pharmacokinetic data | |
| Bioavailability | 89-98% orally |
| Metabolism | ? |
| Half life | 36 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
? |
| Routes | oral |
Clenbuterol is a chemical commonly prescribed to sufferers of breathing disorders as a decongestant and bronchodilator. People with chronic breathing disorders like asthma use this as a bronchodilator to make breathing easier. It is most commonly available in salt form as clenbuterol hydrochloride.
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[edit] Effects and Dosage
Clenbuterol is a β2 adrenergic agonist with some similarities to ephedrine, but its effects are more potent and longer-lasting as a stimulant and thermogenic drug. It causes an increase in aerobic capacity, CNS stimulation, and an increase in blood pressure and oxygen transportation. It increases the rate at which fat and protein is used up in the body at the same time as slowing down the storage of glycogen. It is commonly used for smooth muscle relaxant properties. These mean that it is a bronchodilator, and tocolytic.
[edit] Veterinary use
Clenbuterol is used worldwide for the treatment of allergic respiratory disease in horses as it is a bronchodilator. A common trade name is Ventipulmin. It can be used both orally and intravenously. It is also a non-steroidal anabolic and metabolism accelerator, through a mechanism not well understood. Its ability to induce weight gain and a greater proportion of muscle to fat makes its illegal use in livestock popular. Clenbuterol residues may affect lung and heart function in humans who have eaten liver or meat of animals that are given the drug.[1]
[edit] Food contamination
In September 2006 over 330 people in Shanghai were reported to have been poisoned by eating pork contaminated by clenbuterol that had been fed to the animals to keep their meat lean.[1]
[edit] Legal status
As of fall, 2006, clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. Food and Drug Administration. Clenbuterol is now banned for IOC-tested athletes. Jason Grimsley, former Major League baseball pitcher, admitted to using this drug. The tennis player Mariano Puerta was once penalized for use of clenbuterol.
[edit] References
- ^ "Pigs fed on bodybuilder steroids cause food poisoning in Shanghai", AFP, 2006-09-19. Retrieved on 2006-09-19. (in English)
| Medications commonly used in asthma and COPD (primarily R03) edit | ||
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| Anticholinergics: | ||
| Short acting β2-agonists: | ||
| Long acting β2-agonists (LABA): | Clenbuterol, Formoterol, Salmeterol | |
| Corticosteroids: | ||
| Leukotriene antagonists: | ||
| Xanthines: | ||
| Mast cell stabilizers: | ||
| Combination products: |
Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol |
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[edit] Links
clenbuterol abused as a slimming aid http://www.dailymail.co.uk/pages/live/femail/article.html?in_article_id=409347&in_page_id=1879&in_a_source=
