Chlortetracycline
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Chlortetracycline
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| Systematic (IUPAC) name | |
| (2Z,4S,4aS,5aS,6S,12aS)-2-(amino-hydroxy- methylidene)-7-chloro-4-dimethylamino-6,10,11,12a- tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene- 1,3,12-trione |
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| Identifiers | |
| CAS number | 57-62-5 |
| ATC code | D06AA02 |
| PubChem | 5280963 |
| Chemical data | |
| Formula | C22H23N2ClO8 |
| Mol. weight | 478.879 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 30% |
| Protein binding | 50 to 55% |
| Metabolism | Hepatic (75%) |
| Half life | 5.6 to 9 hours |
| Excretion | Renal and biliary |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | Oral, IV, topical |
Chlortetracycline (trade name Aureomycin®, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. It was discovered in 1945 by Dr Benjamin Dugger in a soil sample from Sanborn Field at the University of Missouri–Columbia, yielding an actinomycete, Streptomyces aureofaciens (hence the name Aureomycin). In veterinary medicine, it is commonly used to treat conjunctivitis in cats.[1]
[edit] References
| Tetracyclines (J01AA) edit | ||
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Chlortetracycline, Demeclocycline, Doxycycline, Lymecycline, Minocycline, Oxytetracycline, Tetracycline |
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