Chlortalidone
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Chlortalidone
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| Systematic (IUPAC) name | |
| 2-chloro-5-(1-hydroxy-3-oxo-1,2-dihydroisoindol-1-yl)- benzenesulfonamide | |
| Identifiers | |
| CAS number | 77-36-1 |
| ATC code | C03BA04 |
| PubChem | 2732 |
| DrugBank | APRD00127 |
| Chemical data | |
| Formula | C14H11N2ClO4S |
| Mol. weight | 338.767 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 75% |
| Metabolism | ? |
| Half life | 40 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral |
Chlortalidone (formerly spelt chlorthalidone in the UK) is a thiazide diuretic, used to treat hypertension.
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| Antihypertensives (C02) and diuretics (C03) edit | ||
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| Antiadrenergic agents (including alpha): |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
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| Other antihypertensives: | ||
| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine |
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| High ceiling diuretics: | ||
| Potassium-sparing diuretics: | ||
