Chlormezanone
From Wikipedia, the free encyclopedia
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Chlormezanone
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| Systematic (IUPAC) name | |
| 2-(4-chlorophenyl)-3-methyl-1, 1-dioxo-1,3-thiazinan-4-one | |
| Identifiers | |
| CAS number | 80-77-3 |
| ATC code | M03BB02 |
| PubChem | 2717 |
| DrugBank | APRD00865 |
| Chemical data | |
| Formula | C11H12ClNO3S |
| Mol. weight | 273.737 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
?(US) |
| Routes | Oral |
Chlormezanone (marketed under the brand name Trancopal) is drug used as an anxiolytic and a muscle relaxant.
It was discontinued worldwide in 1996 by its manufacturer, due to rare but serious cases of toxic epidermal necrolysis.
The image on this page is incorrect. There is no pyridine ring. The chlorine is connected to a benzene ring as is state in the IUPAC name.
[edit] External links
- Wollina U, Hipler U, Seeling A, Oelschlager H. "Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucoytes in vitro.". Skin Pharmacol Physiol 18 (3): 132-8. PMID 15897685.
- Seeling A, Oelschläger H, Rothley D (2000). "Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone". Pharmazie 55 (4): 293-6. PMID 10798243.
- Oelschläger H, Klinger W, Rothley D, Seeling A, Bockhard H, Hofmann B, Machts H, Riederer H, Rackur H (1998). "[Cleavage and biotransformation of the central muscle relaxant chlormezanone]". Pharmazie 53 (9): 620-4. PMID 9770210.
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| Muscle relaxants (M03) edit | ||
|---|---|---|
| Peripherally acting: |
Alcuronium, Atracurium, Cisatracurium, Dimethyltubocurarine, Doxacurium chloride, Fazadinium bromide, Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium bromide, Rocuronium bromide, Suxamethonium, Tubocurarine, Vecuronium |
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| Centrally acting: |
Baclofen, Carisoprodol, Chlormezanone, Chlorzoxazone, Cyclobenzaprine, Febarbamate, Mephenesin, Methocarbamol, Orphenadrine, Phenprobamate, Phenyramidol, Pridinol, Styramate, Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone |
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| Directly acting: | ||
