Chiral column chromatography

From Wikipedia, the free encyclopedia

Chiral column chromatography is a variant of column chromatography, where the stationary phase is chiral instead of achiral. The enantiomers of the same compound then differ in affinity to the stationary phase, thus they exit the column at different times.

The chiral stationary phase can be prepared by attaching a suitable chiral compound to the surface of an achiral support such as silica gel. However, chiral silica gel is much more expensive than normal silica gel.

[edit] See also

Concepts in asymmetric synthesis
Analysis:	Optical rotation, Enantiomeric excess, Diastereomeric excess, Chiral derivitizing agents
Chiral resolution:	Crystallization, Kinetic resolution, Chiral column chromatography
Reactions:	Asymmetric induction, Chiral reagents, Chiral pool synthesis, Chiral auxiliaries, Asymmetric catalytic reduction, Asymmetric catalytic oxidation, Organocatalysis, Biocatalysis